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KMID : 0616120120430040345
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Korean Journal of Pharmacognosy
2012 Volume.43 No. 4 p.345 ~ p.351
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Screening of Korean Herbal Medicines with Inhibitory Activity on Advanced Glycation End Products Formation (VII)
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Choi So-Jin
Kim Young-Sook
Song Yoo-Jin
Lee Yun-Mi
Kim Joo-Hwan
Kim Jin-Sook
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Abstract
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In this study, 49 Korean herbal medicines have been investigated with an in vitro evaluation system using glycation end products (AGEs) formation inhibitory activity. Of these, 18 herbal medicines (IC50<50 μg/ml) were found to have significant AGEs formation inhibitory activity. Of these, five herbal medicines (IC50<10 μg/ml) were found to have significant AGEs formation inhibitory activity. Particularly, Mallotus japonicus (twigs and leaves), Rhus javanica (twigs and leaves), Boehmeria nivea (whole plants), Quercus acuta (stems), and Eurya japonica (stems) showed more potent inhibitory activity (approximately 9-37 fold) than the positive control aminoguanidine (IC50=76.47 μg/ml).
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KEYWORD
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Advanced glycation end products (AGEs) , Diabetic complications , Korean herbal medicines
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